Three days after their 31-3 loss to the Philadelphia Eagles, the Bears return to the practice field Wednesday to begin preparing for Sunday’s home game against the San Francisco 49ers.

The Bears (3-8) have lost four straight games and six of eight since a Week 3 overtime win over the Pittsburgh Steelers at Soldier Field. They’re 2-4 at home this season.

The 49ers (1-10) possess the NFL’s second worst record behind the Cleveland Browns (0-11). San Francisco opened 0-9 before recording its first win of the season, 31-21, over the New York Giants Nov. 12. The 49ers then lost to the Seattle Seahawks 24-13 last weekend.

Quarterback Jimmy Garoppolo will make his first start as a member of the 49ers Sunday against the Bears. The Chicago area native, who attended Rolling Meadows High School and Eastern Illinois University, was acquired by San Francisco from the New England Patriots Oct. 31 in exchange for a second-round draft pick.

Garoppolo replaced an injured C.J. Beathard with 1:07 remaining in last Sunday’s loss to the Seahawks and completed 2 of 2 passes for 19 yards, including a 10-yard touchdown to Louis Murphy on the game’s final play.

The Bears trail the all-time series with the 49ers 33-31-1 but have won five of the last eight matchups. The Bears won the last meeting 26-6 on Dec. 4, 2016 at Soldier Field, played their most complete game of the season as Jordan Howard rushed for 117 yards and a career-high three TDs and the defense held the 49ers to 147 yards, 10 first downs and no touchdowns. Colin Kaepernick was pulled after completing just 1 of 5 passes for four yards while being sacked five times.

Entering Week 12 the Bears rank 29th in offense (8th rushing and 31st passing) and 12th in defense (16th against the run and 12th versus the pass). The 49ers rank 21st in offense (23rd rushing and 17th passing) and 28th in defense (30th against the run and 26th versus the pass).

ChicagoBears.com will provide all the latest news throughout the week from Halas Hall. Coach John Fox will address the media Wednesday, Thursday and Friday. Quarterback Mitchell Trubisky and offensive coordinator Dowell Loggains will be available Wednesday, while defensive coordinator Vic Fangio and special-teams coordinator Jeff Rodgers will speak Thursday.